庆宏

医学博士，bob手机在线登陆生命学院教授，博士生导师

hqing@bit.edu.cn

010-68918409

北京市海淀区中关村bob手机在线登陆5号教学楼688

教育背景：
1993.9-1996.7： 博士，广州中山医科大学，神经生物学

1990.9-1993.7： 硕士，广州中山医科大学，组织胚胎学

1979.9-1983.12：学士，安徽皖南医学院

个人经历：
2010.10-至今：bob手机在线登陆生命学院，教授

2008.10-2010.09：英属哥伦比亚大学神经病学系，脑科学研究中心，研究院

2006.02- 2008.09：bob手机在线登陆生命科学与技术学院，教授
2001.09 – 2006.02：英属哥伦比亚大学精神病学系，脑科学研究中心，助理研究员
2000.07 – 2001.08：加拿大萨斯喀彻温大学，神经精神病学系，博士后
1997.07- 2000.06：美国埃默里大学医学院，放射肿瘤系与细胞生物学研所，博士后
1996.07 – 1997.10：广州中山医科大学，组织胚胎系，神经科学专业，讲师

主要课题研究与经费来源：

2017.01-2019.12：锌指蛋白ZNF335调控BACE1活性及其在阿尔兹海默症病理发生中的研究

国家自然科学基金（81671268） 57万（主持）在研

2016.10-2019.09： 阿尔茨海默病的多模态早期预警诊断技术及其应用研究

北京科学基础重大项目“脑专项研究” （Z161100002616020） 200万（参与）在研

2012.01-2017.12： 空间多指标生物分析仪器开发及应用-核酸芯片的开发

科技部国家重大仪器开发专项（2012YQ040140) 300万元（主持）在研

2012.01-2015.12 ： 早衰因子BACE1的调控与阿尔兹海默症致病机理的研究

国家自然科学基金(81171206) 60万元 （主持）

2009.01-2012.03： 生物安全量值溯源传递关键技术研究(转基因植物蛋白量值溯源传递关键技术研究)

科技部国家科技支撑计划课题(2008BAK41B02) 761万元 （主持）

发表主要论文（2010-2020）：

1. Liu K, Zhao J, Chen C, Xu J, Bell RL, Hall FS, Koob GF, Volkow ND, Qing H, Lin Z.

Epistatic evidence for gender-dependant slow neurotransmission signalling in substance

use disorders: PPP1R12B versus PPP1R1B. EBioMedicine. 2020 Oct 21; 61: 103066.

2. Qazi TJ, Wu Q, Aierken A, Lu D, Bukhari I, Hussain HMJ, Yang J, Mir A, Qing H. Whole-exome sequencing identifies a novel mutation in spermine synthase gene (SMS) associated with Snyder-Robinson Syndrome. BMC Med Genet. 2020 Aug 24; 21(1): 168.

3. Yuan C, Aierken A, Xie Z, Li N, Zhao J, Qing H. The age-related microglial transformation in Alzheimer's disease pathogenesis. Neurobiol Aging. 2020 Aug;92:82-91.

4. Nazir A, Zhao Y, Li M, Manzoor R, Tahir RA, Zhang X, Qing H, Tong Y. Structural Genomics of repA, repB 1-Carrying IncFIB Family pA1705-qnrS, P911021-tetA, and P1642-tetA, Multidrug-Resistant Plasmids from Klebsiella pneumoniae. Infect Drug Resist. 2020 Jun 22; 13:1889-1903.

5. Song D, Wang D, Yang Q, Yan T, Wang Z, Yan Y, Zhao J, Xie Z, Liu Y, Ke Z, Qazi TJ, Li Y, Wu Y, Shi Q, Lang Y, Zhang H, Huang T, Wang C, Quan Z, Qing H. The lateralization of left hippocampal CA3 during the retrieval of spatial working memory. Nat Commun. 2020 Jun 9; 11(1):2901.

6. Xie Z, Yang Q, Song D, Quan Z, Qing H. Optogenetic manipulation of astrocytes from synapses to neuronal networks: A potential therapeutic strategy for neurodegenerative diseases. Glia. 2020 Feb; 68(2):215-226.

7. Tahir RA, Zheng DA, Nazir A, Qing H. A review of computational algorithms for CpG islands detection. J Biosci. 2019 Dec; 44(6):143.

8. Jin W, Qazi TJ, Quan Z, Li N, Qing H. Dysregulation of Transcription Factors: A Key Culprit Behind Neurodegenerative Disorders. Neuroscientist. 2019 Dec;25(6):548-565.

9. Yang L, Xu B, Yuan C, Dai Z, Wang Y, Li Q, Yang Q, Li N, Qing H. The Antioxidative Action of ZTP by Increasing Nrf2/ARE Signal Pathway. Evid Based Complement Alternat Med. 2019 Mar 10; 2019:5421528.

10. Li NM, Liu KF, Qiu YJ, Zhang HH, Nakanishi H, Qing H. Mutations of beta-amyloid precursor protein alter the consequence of Alzheimer's disease pathogenesis. Neural Regen Res. 2019 Apr; 14(4):658-665.

11. Yang L, Ran Y, Quan Z, Wang R, Yang Q, Jia Q, Zhang H, Li Y, Peng Y, Liang J, Wang H, Nakanishi H, Deng Y, Qing H. Pterostilbene, an active component of the dragon's blood extract, acts as an antidepressant in adult rats. Psychopharmacology (Berl). 2019 Jan 4.

12. Li Y, Chen Z, Lu Z, Yang Q, Liu L, Jiang Z, Zhang L, Zhang X, Qing H. "Cell-addictive" dual-target traceable nanodrug for Parkinson's disease treatment via flotillins pathway. Theranostics. 2018 Oct 29; 8(19):5469-5481.

13. Duru LN, Quan Z, Qazi TJ, Qing H. Stem cells technology: a powerful tool behind new brain treatments. Drug Deliv Transl Res. 2018 Oct; 8(5):1564-1591.

14. Song D, Yang Q, Lang Y, Wen Z, Xie Z, Zheng D, Yan T, Deng Y, Nakanishi H, Quan Z, Qing H. Manipulation of hippocampal CA3 firing via luminopsins modulates spatial and episodic short-term memory, especially working memory, but not long-term memory. Neurobiol Learn Mem. 2018 Nov; 155:435-445.

15. Sun Z, Xie Y, Chen Y, Yang Q, Quan Z, Dai R, Qing H. Rab21, a Novel PS1 Interactor, Regulates γ-Secretase Activity via PS1 Subcellular Distribution. Mol Neurobiol. 2018 May; 55(5):3841-3855.

16. Qazi TJ, Quan Z, Mir A, Qing H. Epigenetics in Alzheimer's Disease: Perspective of DNA Methylation. Mol Neurobiol. 2018 Feb; 55(2):1026-1044.

17. Lu J, Xu Y, Quan Z, Chen Z, Sun Z, Qing H. Dysregulated microRNAs in neural system: Implication in pathogenesis and biomarker development in Parkinson's disease. Neuroscience. 2017 Dec 4; 365:70-82.

18. Quan Z, Zheng D, Qing H. Regulatory Roles of Long Non-Coding RNAs in the Central Nervous System and Associated Neurodegenerative Diseases. Front Cell Neurosci. 2017 Jun 30; 11:175.

19. Liang JH, Yang L, Wu S, Liu SS, Cushman M, Tian J, Li NM, Yang QH, Zhang HA, Qiu YJ, Xiang L, Ma CX, Li XM, Qing H. Discovery of efficient stimulators for adult hippocampal neurogenesis based on scaffolds in dragon's blood. Eur J Med Chem. 2017 Aug 18; 136:382-392.

20. Yang Q, Song D, Qing H. Neural changes in Alzheimer's disease from circuit to molecule: Perspective of optogenetics. Neurosci Biobehav Rev. 2017 Aug; 79:110-118.

21. Xu Y, Zhang Y, Quan Z, Wong W, Guo J, Zhang R, Yang Q, Dai R, McGeer PL, Qing H. Epigallocatechin Gallate (EGCG) Inhibits Alpha-Synuclein Aggregation: A Potential Agent for Parkinson's Disease. Neurochem Res. 2016 Oct; 41(10):2788-2796.

22. Wang X, Du J, Wang D, Zeng F, Wei Y, Wang F, Feng C, Li N, Dai R, Deng Y, Quan Z, Qing H. Effects of simulated microgravity on human brain nervous tissue. Neurosci Lett. 2016 Aug 3; 627:199-204.

23. Zhao J, Deng Y, Jiang Z, Qing H. G Protein-Coupled Receptors (GPCRs) in Alzheimer's Disease: A Focus on BACE1 Related GPCRs. Front Aging Neurosci. 2016 Mar 24; 8:58.

24. Li N, Liu K, Qiu Y, Ren Z, Dai R, Deng Y, Qing H. Effect of Presenilin Mutations on APP Cleavage; Insights into the Pathogenesis of FAD.Front Aging Neurosci. 2016 Mar 11; 8:51.

25. Liu Y, Liu K, Qin W, Liu C, Zheng X, Deng Y, Qing H. Effects of stem cell therapy on protein profile of parkinsonian rats using an(18) O-labeling quantitative proteomic approach. Proteomics. 2016 Mar; 16(6):1023-32.

26. Liu K, Liu Y, Li L, Qin P, Iqbal J, Deng Y, Qing H. Glycation alter the process of Tau phosphorylation to change Tau isoforms aggregation property. Biochim Biophys Acta. 2016 Feb; 1862(2):192-201.

27. Ran Y, Xu B, Wang R, Gao Q, Jia Q, Hasan M, Shan S, Ma H, Dai R, Deng Y, Qing H. Dragon's blood extracts reduce radiation-induced peripheral blood injury and protects human megakaryocyte cells from GM-CSF withdraw-induced apoptosis. Phys Med. 2016 Jan; 32(1):84-93.

28. Xu Y, Deng Y, Qing H. The phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's disease. J Neurochem. 2015 Oct; 135(1):4-18.

29. Jia Q, Deng Y, Qing H. Potential therapeutic strategies for Alzheimer's disease targeting or beyond β-amyloid: insights from clinical trials. Biomed Res Int. 2014; 2014:837157.

30. Ran Y, Wang R, Hasan M, Jia Q, Tang B, Shan S, Deng Y, Qing H. Radioprotective effects of dragon's blood and its extracts on radiation-induced myelosuppressive mice. J Ethnopharmacol. 2014 Jul 3; 154(3):624-34.

31. Liu Y, Qing H, Deng Y. Biomarkers in Alzheimer's disease analysis by mass spectrometry-based proteomics. Int J Mol Sci. 2014 May 6; 15(5):7865-82.

32. Ran Y, Wang R, Gao Q, Jia Q, Hasan M, Awan MU, Tang B, Zhou R, Dong Y, Wang X, Li Q, Ma H, Deng Y, Qing H. Dragon's blood and its extracts attenuate radiation-induced oxidative stress in mice. J Radiat Res. 2014 Jul; 55(4):699-706.

33. Ran Y, Wang R, Lin F, Hasan M, Jia Q, Tang B, Xia Y, Shan S, Wang X, Li Q, Deng Y, Qing H. Radioprotective effects of Dragon's blood and its extract against gamma irradiation in mouse bone marrow cells. Phys Med. 2014 Jun; 30(4):427-31.

34. Lu H, Liu X, Deng Y, Qing H. DNA methylation, a hand behind neurodegenerative diseases. Front Aging Neurosci. 2013 Dec 5; 5:85.

35. Gao A, Peng Y, Deng Y, Qing H. Potential therapeutic applications of differentiated induced pluripotent stem cells (iPSCs) in the treatment of neurodegenerative diseases. Neuroscience. 2013 Jan 3; 228:47-59.

36. Wang R, Ying Z, Zhao J, Zhang Y, Wang R, Lu H, Deng Y, Song W, Qing H. Lys(203) and Lys(382) are essential for the proteasomal degradation of BACE1. Curr Alzheimer Res. 2012 Jun;9(5):606-15.

37. Tan Y, Deng Y, Qing H. Calcium channel blockers and Alzheimer's disease. Neural Regen Res. 2012 Jan 15;7(2):137-40.

专利：

1. 一种修饰的β-分泌酶及其应用，20110802，第一，201110219988.7

2. 一种具有苄醇或苄基甲醚取代基的厚朴酚衍生物，第三，CN 104892374 A

3. 一种新型二苯乙烯类衍生物及其制备方法，第二，CN 106008487 A